Customization: | Available |
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CAS No.: | 79-44-7 |
Formula: | C3h6clno |
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Product Name: | Dimethylcarbamoyl chloride |
CAS: | 79-44-7 |
MF: | C3H6ClNO |
MW: | 107.54 |
EINECS: | 201-208-6 |
Melting point | −33 °C(lit.) |
Boiling point | 167-168 °C775 mm Hg(lit.) |
density | 1.168 g/mL at 25 °C(lit.) |
refractive index | n20/D 1.453 |
Fp | 155 °F |
solubility | Chloroform (Soluble), DMSO (Sparingly) |
form | Liquid |
pka | -1.85±0.70(Predicted) |
Specific Gravity | 1.172 |
color | Colorless to Yellow |
Water Solubility | Decomposes |
Sensitive | Moisture Sensitive |
BRN | 878197 |
Exposure limits | ACGIH: TWA 0.005 ppm (Skin) |
Stability: | Moisture Sensitive |
Application: Dimethylcarbamoyl chloride is used as an intermediate in the production of pharmaceuticals, pesticides, and dyes[10]. It is a reagent being capable of transferring a dimethylcarbamoyl group to alcoholic or phenolic hydroxyl groups forming dimethyl carbamates with pharmacological or pesticidal activities[11]. Dimethylcarbamoyl Chloride is also a reagent used in the induction of apoptosis in human lung adenocarcinoma by T-type calcium channel antagonist[12].
Dimethylcarbamoyl chloride is used as the starting material for the insecticide class of the dimethyl carbamates which act as inhibitors of acetylcholinesterase such as dimetilane and the related compounds isolane, pirimicarb and triazamate[13,14].
Dimethylcarbamoyl chloride can be used for the manufacturing of the quaternary ammonium compounds neostigmine, which finds pharmaceutical applications as acetylcholinesterase inhibitors[15].
Dimethylcarbamoyl chloride is also used in the synthesis of the benzodiazepine camazepam[16].